They won't be producing anymore A380s, what's flying now is it. Quad jets are a thing of the past.
Long range, twin-engined jets with ETOPS 330 certification are the norm and have been for a while.
NYC-Tokyo, O'Hare to Istanbul every day. 12-14 hours non-stop, always on a twinjet such as the 787, 777, and A350.
The A380 is now the only regularly scheduled passenger carrying aircraft that has 4 engines.