According to Amtrak's website, they seem to call the "Northeast Region and Northeast Corridor" the same thing.
Not the same thing. Northeast Corridor is the tracks which run from DC to Boston. Northeast Regional is the AMTRAK train service (that you call "route", but I think "route" can be a little confusing in this context) which moves passengers along the NEC, basically the step between the Acela Express and the NJT express trains. Other train services moving passengers on the NEC in our area are NJT NEC, NJT North Jersey Coast Line (for a section of that service), SEPTA, and more. Freight also uses the NEC, and AMTRAK has long-distance train services using the NEC.
For the sake of not arguing with you and lets just say that Northeast Corridor ONLY refers to the line between DC and Boston.
That's nice, and correct as others here have said already.
Would it truly be wise to categorize this entire stretch (no matter what you want to call it) in the DB as ONE LISTING using the same frequency (161.010)? OR should each route be listed separately as Empire Express, Acela Express, Keystone, etc..?
This would depend on whether they ALL use the same frequency.
No! The NEC is broken up into sections, the section by us is the Main Line. Communications are affected by whether the particular train is on the main line or a different line. Other lines use different frequencies, and as mentioned above there are very many services all using the Main Line. This is why the database should identify the frequencies for NEC - Main Line versus other sections of the NEC, instead of saying "the Acela Express between here and here is this but between here and there is that, and by the way all the other trains which run between Acela Express also use the same frequencies as Acela Express."
Nevertheless, it should NOT be called Main Line (which seems more like emoloyee slang) in the db. If anything, call it Northeast Corridor or Northeast Region as Amtrak officially calls it.
As stated before, AMTRAK refers to the NEC. Their customers really don't care what the different sections of it are but scannists certainly do. And the Northeast Regional is one specific AMTRAK service which spans all lines on the NEC.
-Jim
(lest my location throw you, until recently I was a long-term resident of and scannist at Monmouth Junction. Care to know why the town was named that? My home was actually a little closer to Midway.)