You need to research the Prolific driver problem, the chip used in most of the Wouxun, Baeofung programming cables is a Prolific imitation chip, your computer recognizes it as a genuine Prolific chip and load the latest driver THIS DRIVER WILL NO WORK WITH YOUR CABLE, you can find several discussions on this topic, you will need to load an older version driver and follow the instructions then it will work. Once you get it working always plug the programming cable into the same USB port on your computer.