I have used Butel's ARC250 which supports both the 785D and the 250D. The 250D is a handheld version of the 785D. I own both and have been very successful with Butel's ARC250 program.
I don't think ARC250 has an option to connect to the database, but it can download CSV data (which is available when you are a paid subscriber) and grab freqs via the Webcatcher utility. However, Scan Control's CSV import utility is far more powerful, allowing you to download PL information, talkgroups and a lot more. Their URL is: