Start by looking at repeater-builder.com:
http://www.repeater-builder.com/rbtip/repeaterlinking.html
A lot depends on how many repeaters you're linking, and how much money you have to spend. There are several methods, all have their drawbacks... Some some methods have limited functionality, some are very expensive, require LOTS of hardware, and have almost unlimited functionality.
In answer to your question about frequencies, no. You're better if everything can be on a different frequency. But it's not essential, depending on what you have in mind.
Edit: I looked at your other posts and see it's not an amateur repeater you're trying to link. Expect the costs to go up substantially, and the red tape, too. I hope you don't plan on being profitable. Nextel and cellular phone service pretty much killed the two way business for small systems 10 years ago.