I run Probe1k and Probev7 from FreeDOS 1.2, and have used both with DOSBox (often concurrently with FreeDOS).
Is Spectrum Commander worth it? To me it was. The original SC setup at my old shack had 3 Optocoms paired with 3 R-7000s; a PCR-1000 or other gear I was experimenting with was occasionally connected to the 4th of 5 COM ports on the system. I'd let the Optocom/Icom pairs search or scan while I manually controlled the other attached receiver. Sometimes I'd have that one set to scan too.
Hiccups were very few over the course of years of operation. Most were hypervisor or host OS related (as SC was run in a WinXP-Pro VM).
I described a bit of the setup in the PCR-1000 thread, but: 6 PCs (four "signage" types; two more fully featured) control 1ea Optocom, R-7000 and PCR-1000. Each combo is set to scan or search a couple discrete services and each PCR-1000 gets its own ham band to monitor for signs of life. That model was chosen because it's all-mode and is supported by SC; all the watering holes in each band (regardless of mode) can be entered in a scan list then the PCR-1000 set to look for band openings or interesting activity.
None of this would be possible without Spectrum Commander. ScanCAT Gold also supports the Optocom/Optoscan, Icoms (both CI-V and RS-232 such as the PCR) and a number of others. Caveat: It doesn't support multiple receivers concurrently, and it isn't supported on Win7 and later Microsoft OSes. Nevertheless, my WinXP VMs have a licensed copy of it installed. There's also a terminal provision whereas the program can talk to a TNC or multimode decoder. I have one instance of SCG interfaced to a Universal M-7000 for times I want to remotely monitor data comms and cannot get to the decoder itself (like when I have to work...

).
Any of these programs will work nicely for an Optoscan-equipped Pro-2006. All depends on what you want to do with it.