I have all Sheriff channels in knob 1 zone 1, then individual sheriff channels on knob positions 1-7 in that zone. Same thing with zone 2 police and zone 3 fire etc... On another, example zone 4, I have all those zones on separate knob positions 1-8 marked as "All" so I just turn the knob for different zones and that's where the hold comes in handy. I can listen to different zones without stepping down by turning the knob then press hold when I want to stop on a certain channel. If that makes sense. You can have 64 channels in each knob position, 8 different zones.
This is exactly how mine is set up - but I don't have the hold feature yet :--( I hope this feature is released in PPS v. 1.3 which I thought was going to be any week now (or maybe any day now if we're lucky!). For now I have single talk groups per knob position, and on position 8 I have all of them to 'scan' the talk groups.