For standard radios - desktops and portables - for DREAM (which is the software of choice) to work, you would need to tap the detector stage. In theory it's much like putting a discriminator tap in a scanner, but you need to be careful what point you tap. There are various files out there that describe the correct point to tap in many different radios.
SDRs are a different matter. There are a few that have DRM decoding as a native (built in) function (presumably using a version of the Fraunhofer decoder- the decoder on which DREAM is based- on a chip) but for others you would likely need to route the audio via apps like Virtual Audio Cable
Mike