I could work with either frequencies or mnemonics. I came up through ham radio starting with VFO and crystal controlled radios, so when synthesizers hit the market, the only thing we had were frequencies. The KDK FM-2015A and 2016R, and the Yaesu Memorizer were perfect examples. You knew the frequency of whatever repeater because that's all the radio would give you. So, I'm okay with those.
However, I've since started a family and now there are 6 of us, each licensed between Technician and Extra, and each into only so much of the hobby (some folks don't do the total immersion thing and only one of them will pick up the mic and start a random QSO with anyone - but we all use ham radio to stay in touch). So, the frequency display does not work for them. I suppose they could learn what my repeaters are, but if I asked them to switch to another repeater, they'd be lost, and it would be too distracting while driving. So when I go looking for a radio, I don't want one that only does frequency read-out. Now, everything I have has to be uniformly named (I've basically got my own "fleet" of mobiles and portables), so that everybody has common names to refer to things, and very simple features so that they don't get lost in the radio if they inadvertently hit the wrong button.
To that end, I've been buying Kenwood 281s and 481s (wish they made a simple dual-band radio like that) and tossing the DTMF mics, replacing them with the large LMR microphones. Then I program the last 3 letters of the call sign, the frequency band, and an R for repeater, S for simplex, or I for input. This way:
XYZ 2 R = W2XYZ's 2 meter repeater,
XYZ 4 R = W2XYZ's 440 repeater,
XYZ 2 S = the simplex talk-around to W2XYZ's repeater,
XYZ 4 I = the input side, or "reverse" of the repeater (My wife hates to change frequencies while she's driving and if she drives out of range, we can still talk if I hop over to this... or I can listen for interference on it.)
and so on.
If we are infrequent users of someone else's repeater, and will not use the repeater normally, I program in either the club name, or the call sign of the repeater.
Some frequencies, like 146.52, 52.525, 29.6. and 446 specifically, are programmed in as-is.
It seems a little complicated on the front-end, but when we go somewhere and need to chat among ourselves in separate vehicles, everyone has the same thing in front of them and we end up in the right place. Using frequencies for some family members just wouldn't register.