The amount of amplification that this person is talking about would probably require 1 mile of separation and a microwave or telephone link 0r internet link to link the two halves of the repeater together.
The Duplexer would not be able to handle that level of power and keep the transmit out of the receive.
There are duplexers that are rated for that sort of power level that provide in excess of 120 db of TX/RX isolation, but you really missed the point of the problem with this idea.
It's not so much the actual power levels involved, it's amplifying an HT transmitter and preamplifying an HT receiver, THEN running at this power level that is likely to be a problem.
Several critical parameters critical to high power duplex operation is low transmitter noise, and high off-channel receive rejection, neither of which is likely to be sufficient in a pair of HT's. It's not so much of an issue at low power, and there are plenty of low power commercially built repeaters using HT's that work just fine.
You might be better off to find a old Desktrac or other low profile radio repeater system and adapt it to what you wish it to do.
This is the only piece of sound advice I've ever seen you give out.