I use a Windows XP, 32-Bit, for my ancient Motorola CPS for the MTS2000, MCS2000, Professional Series such as the HT & CDM Waris radio, and the Astro 25 for Astro Saber & XTS3000 with USB ports. You have to use an USB to Serial Adapter cable with the Prolific driver, and a RIB.
I believe the 64-Bit operating system will launch the CPS but will not communicate with the radio.