I had the same problem with the older cable, I used this driver bellow and it works fine under Windows 10. You have to do a few steps to get it to install. I will post a link tomorrow its on the other computer.
Ok I used this one Vista-Prolific-USB-2-Serial-Driver-3-2-0-0 there are two links to the drivers both will work with the steps below
here is the discussion at this link where I found the info
https://social.technet.microsoft.co...-usb-driver-not-working?forum=w8itprohardware
https://www.sendspace.com/file/5m5afw
http://www.ztechnology.com/download/Vista-Prolific-USB-2-Serial-Driver-3-2-0-0.exe
when using this one it will install the drivers but you still have to do the steps when you do step 4 choose driver in picture
1. download the driver version 3.3.11.152 in
Prolific USB-to-Serial Comm Port | Magic Driver ( although this is an old driver version, this works in most versions of Windows OS even the latest Windows 8.1 in my case )
2. Go to device manager, under Ports ( COM & LPT ) right click Prolific USB-to-Serial (COMx) then select Update driver software.
3. Browse for driver software on computer
4. Let me pick from a list of devices on my computer
5. Select Have Disk
6. On the bottom, Select Browse and then select location where you saved the driver for 3.3.11.152, you should be able to find ser2pl.
7. Open, then OK, then Next, then VOILA! it should be working now.
8. Scan hardware changes to verify.