It would help to know which scanner you're using to be able to provide specific advice.
The majority of public safety agencies in Horry County use the Horry County trunked radio system, not Palmetto 800. Contrary to what was mentioned, quite a bit of the use of this system is still in the clear. Myrtle Beach PD is the notable exception, as is the Fire/Rescue dispatch channel. But you can still hear HCFR operations traffic. Murrells Inlet Garden City FD has access to both the Horry County system as well as Palmetto 800, and they use the appropriate system for calls in each county.
Horry County Trunking System Profile
www.radioreference.com
Georgetown County public safety exclusively uses Palmetto 800, and is almost entirely in the clear at this time.
Because I like more granular control of what I listen to at any given time, I would set up 3 separate trunked systems in my scanner - one for Horry County TRS, one for Palmetto 800 Horry County, and one for Palmetto 800 Georgetown County. Add talkgroups of interest to each system as preferred. Assign each to different banks/scan lists/favorites list quick keys. I would put Palmetto 800 sites for each county in each respective system - Georgetown County has only one site; Horry County's TRS has only one site; and Palmetto 800 for Horry County has 3 sites - Myrtle Beach, Conway, and North Myrtle Beach. You could consider omitting/locking out/avoiding any of those three sites that cover areas you never visit.
Note that there is a simulcast subsite for the Palmetto 800 Georgetown site in southern Horry County - in the community of Burgess not far from Garden City. So the southern area of Horry will actually be covered by the Georgetown site.
Aside from SC Highway Patrol, you won't hear a lot on Palmetto 800 in Horry County. You'll occasionally hear some channels from adjacent Counties, or from agencies like SCEMD, or SC DPH, and maybe some public transport channels. You'll probably hear some medical helicopter channels while they're active in the Horry County area.
Let me know if you have specific questions.