Right on point here, many repeaters completely depend on a high quality duplexer or external filter to work, and even then they are compromised. Even some commercially made repeaters like the Yaesu Fusion DR-2X are compromised and could use some attention.
The picture below shows what I did to my DR-2X replacing the cheap internal RG-58 jumpers with double shield RG142 and silver plated connectors. Then a Corcom AC input line filter and lots of ferrites (white cubes) over internal cables between radios and controller, many that are unshielded. This repeater had some slight desense on a service monitor with no duplexer and the transmitter into a load when new. Now it’s desense free on a flatpack duplexer.
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BTW, my and probably your DR-2X spews out a lot of transmitter noise when operated on low power 5W and it interferes with its own receiver. Operating these at high power will probable burn up the transmitter, so the only viable power level seems to be mid at 20w. I pad that down to 5w using a high power 6dB attenuator then to a 5w in 85w out amplifier which works well and the repeater runs fairly cool.